Identification of Metabolically Distinct Adipocyte Progenitor Cells in Human Adipose Tissues
نویسندگان
چکیده
منابع مشابه
Identification of White Adipocyte Progenitor Cells In Vivo
The increased white adipose tissue (WAT) mass associated with obesity is the result of both hyperplasia and hypertrophy of adipocytes. However, the mechanisms controlling adipocyte number are unknown in part because the identity of the physiological adipocyte progenitor cells has not been defined in vivo. In this report, we employ a variety of approaches, including a noninvasive assay for follo...
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OBJECTIVE Macrophages are important producers of obesity-induced MCP-1; however, initial obesity-induced increases in MCP-1 production precede M1 macrophage accumulation in visceral adipose tissue (VAT). The initial cellular source of obesity-induced MCP-1 in vivo is currently unknown. Preliminary reports based on in vitro studies of preadipocyte cell lines and adherent stroma-vascular fraction...
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OBJECTIVE Perivascular adipose tissue depots around the aorta are regionally distinct and have specific functional properties. Thoracic aorta perivascular adipose tissue (tPVAT) expresses higher levels of thermogenic genes and lower levels of inflammatory genes than abdominal aorta perivascular adipose tissue (aPVAT). It is not known whether this distinction is due to the in-vivo functional env...
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Department of Medicine, Karolinska Institutet at Karolinska University Hospital, 141 86, Stockholm, Sweden, Institute for Theoretical Biology (ITB), Humboldt University Berlin and Charité, Invalidenstrasse 43, 10115 Berlin, Germany, Department of Cell and Molecular Biology, Karolinska Institutet, 171 77 Stockholm, Sweden, Department of Mathematics, Stockholm University, 106 91 Stockholm, Sweden...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2019
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2019.04.010